G6b-B Inhibits Constitutive and Agonist-induced Signaling by Glycoprotein VI and CLEC-2*
نویسندگان
چکیده
Jun Mori, Andrew C. Pearce, Jennifer C. Spalton, Beata Grygielska, Johannes A. Eble, Michael G. Tomlinson, Yotis A. Senis, and Steve P. Watson From the Centre for Cardiovascular Sciences, Institute of Biomedical Research, University of Birmingham, B15 2TT, United Kingdom and the Center for Molecular Medicine, Department of Vascular Matrix Biology, Excellence Cluster Cardio-Pulmonary System, Frankfurt University Hospital, 60590 Frankfurt am Main, Germany
منابع مشابه
G6b-B Inhibits Constitutive and Agonist-induced Signaling by Glycoprotein VI and CLEC-2*S⃞
Platelets play an essential role in wound healing by forming thrombi that plug holes in the walls of damaged blood vessels. To achieve this, platelets express a diverse array of cell surface receptors and signaling proteins that induce rapid platelet activation. In this study we show that two platelet glycoprotein receptors that signal via an immunoreceptor tyrosine-based activation motif (ITAM...
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Platelets are highly reactive cell fragments that adhere to exposed extracellular matrix (ECM) and prevent excessive blood loss by forming clots. Paradoxically, megakaryocytes, which produce platelets in the bone marrow, remain relatively refractory to the ECM-rich environment of the bone marrow despite having the same repertoire of receptors as platelets. These include the ITAM (immunoreceptor...
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Carcinoembryonic antigen-related cell adhesion molecule-2 (CEACAM2) is a cell-surface glycoprotein expressed on blood, epithelial, and vascular cells. CEACAM2 possesses adhesive and signaling properties mediated by immunoreceptor tyrosine-based inhibitory motifs. In this study, we demonstrate that CEACAM2 is expressed on the surface and in intracellular pools of platelets. Functional studies of...
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